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The widespread use of distributed energy sources (DERs) raises significant challenges for power system design, planning, and operation, leading to wide adaptation of tools on hosting capacity analysis (HCA). Traditional HCA methods conduct extensive power flow analysis. Due to the computation burden, these time-consuming methods fail to provide online hosting capacity (HC) in large distribution systems. To solve the problem, we first propose a deep learning-based problem formulation for HCA, which conducts offline training and determines HC in real time. The used learning model, long short-term memory (LSTM), implements historical time-series data to capture periodical patterns in distribution systems. However, directly applying LSTMs suffers from low accuracy due to the lack of consideration on spatial information, where location information like feeder topology is critical in nodal HCA. Therefore, we modify the forget gate function to dual forget gates, to capture the spatial correlation within the grid. Such a design turns the LSTM into the Spatial-Temporal LSTM (ST-LSTM). Moreover, as voltage violations are the most vital constraints in HCA, we design a voltage sensitivity gate to increase accuracy further. The results of LSTMs and ST-LSTMs on feeders, such as IEEE 34-, 123-bus feeders, and utility feeders, validate our designs. 

Abstract Motivation Cancer is caused by the accumulation of somatic mutations that lead to the formation of distinct populations of cells, called clones. The resulting clonal architecture is the main cause of relapse and resistance to treatment. With decreasing costs in DNA sequencing technology, rich cancer genomics datasets with many spatial sequencing samples are becoming increasingly available, enabling the inference of high-resolution tumor clones and prevalences across different spatial coordinates. While temporal and phylogenetic aspects of tumor evolution, such as clonal evolution over time and clonal response to treatment, are commonly visualized in various clonal evolution diagrams, visual analytics methods that reveal the spatial clonal architecture are missing. Results This article introduces ClonArch, a web-based tool to interactively visualize the phylogenetic tree and spatial distribution of clones in a single tumor mass. ClonArch uses the marching squares algorithm to draw closed boundaries representing the presence of clones in a real or simulated tumor. ClonArch enables researchers to examine the spatial clonal architecture of a subset of relevant mutations at different prevalence thresholds and across multiple phylogenetic trees. In addition to simulated tumors with varying number of biopsies, we demonstrate the use of ClonArch on a hepatocellular carcinoma tumor with ∼280 sequencing biopsies. ClonArch provides an automated way to interactively examine the spatial clonal architecture of a tumor, facilitating clinical and biological interpretations of the spatial aspects of intra-tumor heterogeneity. Availability and implementation https://github.com/elkebir-group/ClonArch. 

Conversational systems typically focus on functional tasks such as scheduling appointments or creating todo lists. Instead we design and evaluate SlugBot (SB), one of 8 semifinalists in the 2018 AlexaPrize, whose goal is to support casual open-domain social inter-action. This novel application requires both broad topic coverage and engaging interactive skills. We developed a new technical approach to meet this demanding situation by crowd-sourcing novel content and introducing playful conversational strategies based on storytelling and games. We collected over 10,000 conversations during August 2018 as part of the Alexa Prize competition. We also conducted an in-lab follow-up qualitative evaluation. Over-all users found SB moderately engaging; conversations averaged 3.6 minutes and involved 26 user turns. However, users reacted very differently to different conversation subtypes. Storytelling and games were evaluated positively; these were seen as entertaining with predictable interactive structure. They also led users to impute personality and intelligence to SB. In contrast, search and general Chit-Chat induced coverage problems; here users found it hard to infer what topics SB could understand, with these conversations seen as being too system-driven. Theoretical and design implications suggest a move away from conversational systems that simply provide factual information. Future systems should be designed to have their own opinions with personal stories to share, and SB provides an example of how we might achieve this.